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Lookup NU author(s): Professor Nicholas EmbletonORCiD,
Dr Claire Granger,
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© 2022 S. Karger AG, Basel. The last 20 years have seen dramatic improvements in survival for preterm infants in both high- and low-income settings. Survival rates of over 50% in infants born 16 weeks early (24 weeks' gestation) are now commonplace in well-resourced neonatal intensive care units. However, ensuring adequate nutrient intakes especially in the first few days and weeks is challenging, and many infants show poor growth and nutritional status. Good nutritional management should be seen as the cornerstone of good neonatal care and is key to improving a range of important outcomes including reduced rates of retinopathy of prematurity, chronic lung disease, necrotizing enterocolitis (NEC), and sepsis. Equally importantly, is that good nutritional status is essential to optimize brain growth and differentiation. There are multiple potential mechanisms that link nutrition to brain outcomes in preterm infants including needs for tissue accretion, energy supply, signaling roles, functional components in human milk, epigenetic regulation, prevention of NEC and disease, and impacts on the gut brain axes. This article will review data in support of different mechanistic links for the impact of nutrition on brain outcomes in preterm infants.
Author(s): Embleton ND, Granger C, Chmelova K
Editor(s): Nicholas D. Embleton, Ferdinand Haschke, Lars Bode
Publication type: Book Chapter
Publication status: Published
Book Title: Strategies in Neonatal Care to Promote Optimized Growth and Development: Focus on Low Birth Weight Infants
Print publication date: 28/02/2022
Acceptance date: 02/04/2018
Series Title: Nestle Nutrition Institute Workshop Series
Place Published: Basel
PubMed id: 35537423
Notes: 96th Nestlé Nutrition Institute Workshop, May 2021. Session 1: Optimizing Feeding, Nutrition and Growth on the NICU and after Discharge.
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