Toggle Main Menu Toggle Search

Open Access padlockePrints

Heart Transplantation in Children With Down Syndrome

Lookup NU author(s): Dr Zdenka Reinhardt



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. BACKGROUND: Children with Down syndrome (DS) have a high risk of cardiac disease that may prompt consideration for heart transplantation (HTx). However, transplantation in patients with DS is rarely reported. This project aimed to collect and describe waitlist and post– HTx outcomes in children with DS. METHODS AND RESULTS: This is a retrospective case series of children with DS listed for HTx. Pediatric HTx centers were identified by their participation in 2 international registries with centers reporting HTx in a patient with DS providing detailed demographic, medical, surgical, and posttransplant outcome data for analysis. A total of 26 patients with DS were listed for HTx from 1992 to 2020 (median age, 8.5 years; 46% male). High-risk or failed repair of congenital heart disease was the most common indication for transplant (N=18, 69%). A total of 23 (88%) patients survived to transplant. All transplanted patients survived to hospital discharge with a median posttransplant length of stay of 22 days. At a median posttransplant follow-up of 2.8 years, 20 (87%) patients were alive, 2 (9%) developed posttransplant lymphoproliferative disorder, and 8 (35%) were hospitalized for infection within the first year. Waitlist and posttransplant outcomes were similar in patients with and without DS (P=non-significant for all). CONCLUSIONS: Waitlist and post-HTx outcomes in children with DS selected for transplant listing are comparable to pediatric HTx recipients overall. Given acceptable outcomes, the presence of DS alone should not be considered an absolute contrain-dication to HTx.

Publication metadata

Author(s): Godown J, Fountain D, Bansal N, Ameduri R, Anderson S, Beasley G, Burstein D, Knecht K, Molina K, Pye S, Richmond M, Spinner JA, Watanabe K, West S, Reinhardt Z, Scheel J, Urschel S, Villa C, Hollander SA

Publication type: Article

Publication status: Published

Journal: Journal of the American Heart Association

Year: 2022

Volume: 11

Issue: 10

Online publication date: 16/05/2022

Acceptance date: 22/02/2022

Date deposited: 07/06/2022

ISSN (electronic): 2047-9980

Publisher: American Heart Association Inc.


DOI: 10.1161/JAHA.121.024883

PubMed id: 35574952


Altmetrics provided by Altmetric


Funder referenceFunder name
UL1 TR002243