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Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people with HIV

Lookup NU author(s): Dr Matthew Hunt, Rosa Mitchelmore, Dr Brendan PayneORCiD

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Abstract

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from thymidine analogue to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not thymidine analogue-treated PWH. These data support the continued use of TDF in resource-limited settings.

Publication metadata

Author(s): Hunt M, Phillips R, Hardy Y, Owusu DO, Mitchelmore R, Durrani M, Payne BAI, Chadwick DR

Publication type: Article

Publication status: Published

Journal: AIDS

Year: 2022

Volume: 36

Issue: 7

Pages: 1049-1051

Print publication date: 01/06/2022

Acceptance date: 03/02/2022

ISSN (print): 0269-9370

ISSN (electronic): 1473-5571

Publisher: Lippincott, Williams & Wilkins

URL: https://doi.org/10.1097/QAD.0000000000003209

DOI: 10.1097/QAD.0000000000003209

PubMed id: 35652677

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