Toggle Main Menu Toggle Search

Open Access padlockePrints

IMMUNOLOGY Mapping the developing human immune system across organs

Lookup NU author(s): Issac Goh, Dr Laura JardineORCiD, Dr Rachel Botting, Dr Emily StephensonORCiD, Justin Engelbert, Rasa Elmentaite, Mohi Miah, Dave Horsfall, Professor Muzlifah Haniffa


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Copyright © 2022 the authors. Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.

Publication metadata

Author(s): Suo C, Dann E, Goh I, Jardine L, Kleshchevnikov V, Park J-E, Botting RA, Stephenson E, Engelbert J, Tuong ZK, Polanski K, Yayon N, Xu C, Suchanek O, Elmentaite R, Conde CD, He P, Pritchard S, Miah M, Moldovan C, Steemers AS, Mazin P, Prete M, Horsfall D, Marioni JC, Clatworthy MR, Haniffa M, Teichmann SA

Publication type: Article

Publication status: Published

Journal: Science

Year: 2022

Volume: 376

Issue: 6597

Print publication date: 03/06/2022

Online publication date: 12/05/2022

Acceptance date: 02/05/2022

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science


DOI: 10.1126/science.abo0510

PubMed id: 35549310


Altmetrics provided by Altmetric