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TGF-β, to target or not to target; to prevent thyroid cancer progression?

Lookup NU author(s): ISHA Karnik, Rachel Telfer-Sutherland, Dr Joanna Elson, Sebastian Aspinall, Dr Annette Meeson


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© 2022 Elsevier B.V.Thyroid cancer (TC) is a common endocrine cancer with a rising incidence. Current treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the processes that cause disease progression. In this review, we provide insight into TGF-β driven epithelial to mesenchymal transition (EMT), summarizing the current literature surrounding thyroid carcinogenesis, and discuss the potential for therapeutic strategies targeting the TGF-β signalling pathway. Understanding the underlying mechanisms that regulate cancer stem cell (CSC) growth and TGF-β signalling may provide novel therapeutic approaches for highly resistant TCs.

Publication metadata

Author(s): Karnik I, Sutherland R, Elson J, Aspinall S, Meeson A

Publication type: Review

Publication status: Published

Journal: Biochimica et Biophysica Acta - Reviews on Cancer

Year: 2022

Volume: 1877

Issue: 4

Print publication date: 01/07/2022

Online publication date: 18/06/2022

Acceptance date: 14/06/2022

ISSN (print): 0304-419X

ISSN (electronic): 1879-2561

Publisher: Elsevier B.V.


DOI: 10.1016/j.bbcan.2022.188752

PubMed id: 35728736