Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

TGF-β, to target or not to target; to prevent thyroid cancer progression?

Lookup NU author(s): ISHA Karnik, Rachel Telfer-Sutherland, Dr Joanna ElsonORCiD, Sebastian Aspinall, Dr Annette Meeson

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© 2022 Elsevier B.V.Thyroid cancer (TC) is a common endocrine cancer with a rising incidence. Current treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the processes that cause disease progression. In this review, we provide insight into TGF-β driven epithelial to mesenchymal transition (EMT), summarizing the current literature surrounding thyroid carcinogenesis, and discuss the potential for therapeutic strategies targeting the TGF-β signalling pathway. Understanding the underlying mechanisms that regulate cancer stem cell (CSC) growth and TGF-β signalling may provide novel therapeutic approaches for highly resistant TCs.

Publication metadata

Author(s): Karnik I, Sutherland R, Elson J, Aspinall S, Meeson A

Publication type: Review

Publication status: Published

Journal: Biochimica et Biophysica Acta - Reviews on Cancer

Year: 2022

Volume: 1877

Issue: 4

Print publication date: 01/07/2022

Online publication date: 18/06/2022

Acceptance date: 14/06/2022

ISSN (print): 0304-419X

ISSN (electronic): 1879-2561

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.bbcan.2022.188752

DOI: 10.1016/j.bbcan.2022.188752

PubMed id: 35728736

Share