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Mitochondrial dysfunction in cell senescence and aging

Lookup NU author(s): Dr Satomi Miwa, Professor Thomas von Zglinicki



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential, typically accompanied by increased production of oxygen free radicals, is a cause and a consequence of cellular senescence and figures prominently in multiple feedback loops that induce and maintain the senescent phenotype. Here, we summarize pathways that cause mitochondrial dysfunction in senescence and aging and discuss the major consequences of mitochondrial dysfunction and how these consequences contribute to senescence and aging. We also highlight the potential of senescence-associated mitochondrial dysfunction as an antiaging and antisenescence intervention target, proposing the combination of multiple interventions converging onto mitochondrial dysfunction as novel, potent senolytics.

Publication metadata

Author(s): Miwa S, Kashyap S, Chini E, von Zglinicki T

Publication type: Review

Publication status: Published

Journal: Journal of Clinical Investigation

Year: 2022

Volume: 132

Issue: 13

Print publication date: 01/07/2022

Online publication date: 01/07/2022

Acceptance date: 02/04/2018

ISSN (print): 0021-9738

ISSN (electronic): 1558-8238

Publisher: American Society for Clinical Investigation


DOI: 10.1172/JCI158447

PubMed id: 35775483