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Lookup NU author(s): Dr Satomi Miwa,
Professor Thomas von Zglinicki
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential, typically accompanied by increased production of oxygen free radicals, is a cause and a consequence of cellular senescence and figures prominently in multiple feedback loops that induce and maintain the senescent phenotype. Here, we summarize pathways that cause mitochondrial dysfunction in senescence and aging and discuss the major consequences of mitochondrial dysfunction and how these consequences contribute to senescence and aging. We also highlight the potential of senescence-associated mitochondrial dysfunction as an antiaging and antisenescence intervention target, proposing the combination of multiple interventions converging onto mitochondrial dysfunction as novel, potent senolytics.
Author(s): Miwa S, Kashyap S, Chini E, von Zglinicki T
Publication type: Review
Publication status: Published
Journal: Journal of Clinical Investigation
Print publication date: 01/07/2022
Online publication date: 01/07/2022
Acceptance date: 02/04/2018
ISSN (print): 0021-9738
ISSN (electronic): 1558-8238
Publisher: American Society for Clinical Investigation
PubMed id: 35775483