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What’s new in atopic eczema? An analysis of systematic reviews published in 2019. Part 2: treatment

Lookup NU author(s): Dr Bayanne Olabi



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021 The Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This review forms part of a series of annual evidence updates on atopic eczema (AE), and provides a summary of key findings from systematic reviews (SRs) published or indexed in 2019 related to AE treatment. Several SRs assessed the efficacy of topical corticosteroids (TCS), topical calcineurin inhibitors, topical phosphodiesterase-4 inhibitors and topical Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway inhibitors. However, there is a lack of good-quality trials comparing topical treatment agents with TCS, which remain the standard of care for patients with AE. Most of the included trials lack meaningful comparisons as they used vehicle as a comparator. There is also lack of harmonization of outcome measures for AE across studies. Large, well-designed RCTs are needed to further determine whether any specific emollients offer superior benefit. There is evidence highlighting limited benefit of oral H1 antihistamines as ‘add-on’ therapy to topical treatment of eczema. Mycophenolate mofetil may have a role in patients with refractory AE. Among biologic therapies, most of the efficacy data relate to dupilumab. Furthermore, there is growing evidence for the efficacy and safety of systemic JAK/STAT pathway inhibitors, but the existing data are of low quality.

Publication metadata

Author(s): Marrouche N, Lancaster N, Grindlay DJC, Rogers NK, Olabi B

Publication type: Review

Publication status: Published

Journal: Clinical and Experimental Dermatology

Year: 2021

Volume: 46

Issue: 7

Pages: 1211-1215

Print publication date: 01/10/2021

Online publication date: 03/06/2021

Acceptance date: 31/05/2021

ISSN (print): 0307-6938

ISSN (electronic): 1365-2230

Publisher: John Wiley and Sons Inc


DOI: 10.1111/ced.14775

PubMed id: 34080205