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Lookup NU author(s): Dr Bayanne Olabi
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 The Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This review forms part of a series of annual evidence updates on atopic eczema (AE), and provides a summary of key findings from systematic reviews (SRs) published or indexed in 2019 related to AE treatment. Several SRs assessed the efficacy of topical corticosteroids (TCS), topical calcineurin inhibitors, topical phosphodiesterase-4 inhibitors and topical Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway inhibitors. However, there is a lack of good-quality trials comparing topical treatment agents with TCS, which remain the standard of care for patients with AE. Most of the included trials lack meaningful comparisons as they used vehicle as a comparator. There is also lack of harmonization of outcome measures for AE across studies. Large, well-designed RCTs are needed to further determine whether any specific emollients offer superior benefit. There is evidence highlighting limited benefit of oral H1 antihistamines as ‘add-on’ therapy to topical treatment of eczema. Mycophenolate mofetil may have a role in patients with refractory AE. Among biologic therapies, most of the efficacy data relate to dupilumab. Furthermore, there is growing evidence for the efficacy and safety of systemic JAK/STAT pathway inhibitors, but the existing data are of low quality.
Author(s): Marrouche N, Lancaster N, Grindlay DJC, Rogers NK, Olabi B
Publication type: Review
Publication status: Published
Journal: Clinical and Experimental Dermatology
Year: 2021
Volume: 46
Issue: 7
Pages: 1211-1215
Print publication date: 01/10/2021
Online publication date: 03/06/2021
Acceptance date: 31/05/2021
ISSN (print): 0307-6938
ISSN (electronic): 1365-2230
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/ced.14775
DOI: 10.1111/ced.14775
PubMed id: 34080205
