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The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach

Lookup NU author(s): Professor Paolo MissierORCiD


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© 2022The post-acute COVID-19 syndrome (PACS) is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase. Current data suggests that at least 10% of people with previously documented infection may develop PACS, and up to 50–80% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory.

Publication metadata

Author(s): Guaraldi G, Milic J, Cesari M, Leibovici L, Mandreoli F, Missier P, Rozzini R, Cattelan AM, Motta F, Mussini C, Cossarizza A

Publication type: Review

Publication status: Published

Journal: Ageing Research Reviews

Year: 2022

Volume: 81

Print publication date: 01/11/2022

Online publication date: 09/07/2022

Acceptance date: 07/07/2022

ISSN (print): 1568-1637

ISSN (electronic): 1872-9649

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.arr.2022.101686

PubMed id: 35820609