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Survival outcomes for patients with nasopharyngeal carcinoma in non–endemic region in the UK treated with intensity modulated based radiotherapy 65 Gy in 30 fractions ± weekly cisplatin chemotherapy

Lookup NU author(s): Dr Shahid Iqbal, James O'HaraORCiD, Dr Charles Kelly

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

© 2022. Greater Poland Cancer CentreBackground: Nasopharyngeal carcinoma (NPC) is rare in the UK. The aim of the current study was to investigate survival outcomes for patients with NPC treated with (chemo)radiotherapy using 65 Gy in 30 fractions in a non-endemic region. Materials and methods: All consecutive 62 patients with histology proven non-metastatic nasopharyngeal carcinoma diagnosed between January 2009 to June 2019 were included in this retrospective analysis. Results: Median age was 59 years (range:19–81). The majority of patients had stage III disease (66.1%). Induction chemotherapy was given in 21%of patients and 82.3%of patients received concomitant systemic therapy. All patients were treated with 65 Gy in 30 fractions. There was disease recurrence in 17.4%patients. The 5-year disease-free, disease-specific and overall survival were 81.9%, 79.2%and 76.4%, respectively. On univariate analysis, disease recurrence was associated with N-stage (p = 0.047) and overall stage group (p = 0.023). Conclusion: To the best of authors’ knowledge, this is the first report of the use of 65 Gy in 30 fractions of radiotherapy ± weekly cisplatin chemotherapy in NPC in a real-world setting. Our results are comparable to that from other non-endemic regions of the world using different dose fractionation of (chemo)radiotherapy. Future randomised control trials are warranted to compare various dose fractionations in these settings

Publication metadata

Author(s): Iqbal MS, Tin A, Mian A, Ali A, O'Hara J, Kovarik J, Patil R, Aynsley E, Kelly C

Publication type: Article

Publication status: Published

Journal: Reports of Practical Oncology and Radiotherapy

Year: 2022

Volume: 27

Issue: 3

Pages: 401-409

Online publication date: 01/06/2022

Acceptance date: 02/04/2018

Date deposited: 23/06/2023

ISSN (print): 1507-1367

Publisher: Via Medica

URL: https://doi.org/10.5603/RPOR.a2022.0062

DOI: 10.5603/RPOR.a2022.0062

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