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Synchronization of Cocrystal Dissolution and Drug Precipitation to Sustain Drug Supersaturation

Lookup NU author(s): Dr Tatiane Machado, Dr Oisín KavanaghORCiD

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Abstract

A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal dissolution-drug supersaturation-precipitation (DSP) behavior. The important effects of coformer concentration, cocrystal dose, and cocrystal solubility on drug supersaturation levels are demonstrated and quantified by the DSPindex. While the studies presented rely on high and nonstoichiometric coformer concentrations contributed by the dissolving cocrystals, the concepts and findings can answer the question of whether and how much coformer should be added to cocrystal dissolution media or formulations.

Publication metadata

Author(s): Cogo Machado T, Kavanagh ON, Goncalves Cardoso S, Rodriguez-Hornedo N

Publication type: Article

Publication status: Published

Journal: Molecular pharmaceutics

Year: 2022

Volume: 19

Issue: 8

Pages: 2765-2775

Print publication date: 01/08/2022

Online publication date: 14/07/2022

Acceptance date: 27/05/2022

ISSN (print): 1543-8384

ISSN (electronic): 1543-8392

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acs.molpharmaceut.2c00122

DOI: 10.1021/acs.molpharmaceut.2c00122

PubMed id: 35833828

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