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Diagnosis and treatment of thrombotic microangiopathy

Lookup NU author(s): Dr Gemma Thompson, Professor David KavanaghORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Thrombotic microangiopathy (TMA) is characterised by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground-breaking research into the pathogenesis of TMAs over the past 20 years has driven the successful development of targeted therapeutics revolutionising patient outcomes. This review outlines the clinical presentations, pathogenesis, diagnostic tests and treatments for TMAs.

Publication metadata

Author(s): Thompson GL, Kavanagh D

Publication type: Article

Publication status: Published

Journal: International Journal of Laboratory Hematology

Year: 2022

Volume: 44

Issue: S1

Pages: 101-113

Online publication date: 08/09/2022

Acceptance date: 28/07/2022

Date deposited: 16/08/2022

ISSN (print): 1751-5521

ISSN (electronic): 1751-553X

Publisher: Wiley-Blackwell Publishing Ltd


DOI: 10.1111/ijlh.13954


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