Toggle Main Menu Toggle Search

Open Access padlockePrints

Study of Some Toxicological Aspects of Titanium Dioxide Nanoparticles Through Oxidative Stress, Genotoxicity, and Histopathology in Tilapia, Oreochromis mossambicus

Lookup NU author(s): Dr Farhat Jabeen, Dr Abdul ChaudhryORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. Extensive use of nanotechnology in multiple commodities is raising concerns about nanotoxicity. In particular, many studies have reported the health-hazardous effects of titanium dioxide nanoparticles (TiO2-NPs). The present study focuses on the toxicity and accumulation of TiO2-NPs in tilapia (Oreochromis mossambicus). For this purpose, tilapia was kept in water tanks, acclimatized for 14 days, and treated with different doses of TiO2 nanoparticles: 0, 0.5, 1.0, and 1.5 mg TiO2-NPs/L. Results revealed an increase in the accumulation of TiO2-NPs with an increase in doses. Moreover, with a higher dose (1.5 mg/L), gills had maximum levels compared to muscles and liver tissues, whereas other doses showed different accumulation patterns. Catalase, glutathione, and lipid peroxidation levels were significantly higher in the gills, and superoxide dismutase levels were significantly higher in the liver. Characteristics like thickening and fusion in lamellae, rupturing of gill filaments, and hyperplasia of gills were also recorded. The phenomenon of increased necrosis and apoptosis in the liver was also noticed with increasing concentration of TiO2-NPs along with the formation of sinusoid spaces and condensed nuclear bodies. Elevated values of olive tail movement and % tail DNA were also noticed with an increased concentration of TiO2-NPs. This study concluded that TiO2-NPs produced oxidative stress by accumulation in soft tissues and induced pathology and genotoxicity.

Publication metadata

Author(s): Shahzad K, Khan MN, Jabeen F, Chaudhry AS, Khan MKA, Ara C, Khan MS

Publication type: Article

Publication status: Published

Journal: BioNanoScience

Year: 2022

Volume: 12

Pages: 1116-1124

Print publication date: 01/12/2022

Online publication date: 10/08/2022

Acceptance date: 05/08/2022

ISSN (print): 2191-1630

ISSN (electronic): 2191-1649

Publisher: Springer Nature


DOI: 10.1007/s12668-022-01024-7


Altmetrics provided by Altmetric