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Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?

Lookup NU author(s): Dr Polina YarovaORCiD

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Abstract

Copyright ©The authors 2022. For reproduction rights and permissions contact permissions@ersnet.org. In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.

Publication metadata

Author(s): Riccardi D, Ward JPT, Yarova PL, Janssen LJ, Lee TH, Ying S, Corrigan CJ

Publication type: Review

Publication status: Published

Journal: European Respiratory Journal

Year: 2022

Volume: 60

Issue: 2

Online publication date: 10/08/2022

Acceptance date: 16/12/2021

ISSN (print): 0903-1936

ISSN (electronic): 1399-3003

Publisher: NLM (Medline)

URL: https://doi.org/10.1183/13993003.02103-2021

DOI: 10.1183/13993003.02103-2021

PubMed id: 35058244

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