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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Lookup NU author(s): Emeritus Professor Thomas Kirkwood

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2022 Schmauck-Medina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

Publication metadata

Author(s): Schmauck-Medina T, Moliere A, Lautrup S, Zhang J, Chlopicki S, Madsen HB, Cao S, Soendenbroe C, Mansell E, Vestergaard MB, Li Z, Shiloh Y, Opresko PL, Egly J-M, Kirkwood T, Verdin E, Bohr VA, Cox LS, Stevnsner T, Rasmussen LJ, Fang EF

Publication type: Article

Publication status: Published

Journal: Aging

Year: 2022

Volume: 14

Issue: 16

Pages: 6829-6839

Online publication date: 29/08/2022

Acceptance date: 14/08/2022

Date deposited: 03/10/2022

ISSN (electronic): 1945-4589

Publisher: Impact Journals LLC

URL: https://doi.org/10.18632/aging.204248

DOI: 10.18632/aging.204248

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