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Lookup NU author(s): Serlie Fatrin, Dr Nduka Okwose, Dr Guy MacGowanORCiD, Professor Djordje JakovljevicORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022, The Author(s). Background: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure. Methods: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire. Results: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O2 consumption (r = − 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = − 0.08, p = 0.60). Conclusion: Peak O2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.
Author(s): Fatrin S, Okwose NC, Bailey K, Velicki L, Popovic D, Ristic A, Seferovic PM, MacGowan GA, Jakovljevic DG
Publication type: Article
Publication status: Published
Journal: BMC Cardiovascular Disorders
Year: 2022
Volume: 22
Issue: 1
Online publication date: 16/09/2022
Acceptance date: 18/08/2022
Date deposited: 03/10/2022
ISSN (electronic): 1471-2261
Publisher: BioMed Central Ltd
URL: https://doi.org/10.1186/s12872-022-02829-w
DOI: 10.1186/s12872-022-02829-w
PubMed id: 36114473
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