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Dynamic materials for optimisation of therapies

Lookup NU author(s): Dr Katarina Novakovic


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Hydrogels, hydrogel composites and hydrogel based polymeric oscillators, as drug delivery systems, tissue engineering and immunomodulatory therapies, are emerging cost effective solutions for a broad range of conditions. Revolving around hydrogel porous structure which can serve as a drug reservoir but also scaffold for cells to migrate into, these versatile materials are attracting interest of a broader range of scientific communities. Work presented here focuses on biocompatible chitosan based hydrogels fit for drug delivery, immunomodulatory therapy and tissue engineering applications. Studies discussed include injectable, implantable and transdermal formulations. Relevance of in vitro and in vivo biocompatibility studies as well as biodegradation strategies is also discussed. Approaches towards controlled and prolonged drug dosing are explored and most recent data shared. Going further into complex drug dosing schedules, hydrogel based polymeric oscillators are also showcased. Pulsatile gels are primarily associated with only two research groups worldwide, Yoshida’s research group, Tokyo University and the Novakovic research group, Newcastle University. The ultimate aim in linking oscillatory chemical systems with polymer science is the development of useful materials and devices that otherwise would not be feasible. The vision includes fully self-oscillatory materials, materials that act life-like, materials that are able to carry and dispense their content in predefined rhythms, and materials which can generate environment which favors cell self-assembly into functional tissues.Physical Chemistry 2022 • Society of Physical Chemists of Serbia (

Publication metadata

Author(s): Novakovic K

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Physical Chemistry 2022 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry

Year of Conference: 2022

Online publication date: 26/09/2022

Acceptance date: 26/07/2022

Publisher: The Society of Physical Chemists of Serbia