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Lookup NU author(s): Dr Michaela Goodson, Professor Claire Walsh
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Springer Nature , 2022.
For re-use rights please refer to the publisher's terms and conditions.
© 2022, The Author(s), under exclusive licence to Springer Nature B.V. The Akaki River in the Upper Awash Basin, which flows through Addis Ababa, the capital city of Ethiopia, has been highly polluted by sewage from factories and residential areas. A population-based cross-sectional study was used to assess the association between trace elements and kidney injury from residents living in polluted areas downstream (Akaki-Kality) versus upstream (Gullele) in Sub-Cities of Addis Ababa. A total of 95 individuals (53 from Akaki-Kality and 42 from Gullele) were included in the study. Kidney injury molecule 1 (KIM-1), lead, arsenic, cadmium, cobalt, lead, manganese, zinc, iron, copper, chromium and nickel were evaluated in residents’ urine and nail samples. A large proportion (74%) of the sample population contained KIM-1, including 81% residents in Akaki-Kality and 64% residents in Gullele. KIM-1 was, however, not significantly different (p = 0.05) between the two Sub-Cities, with median of 0.224 ng/mL in Akaki-Kality and 0.152 ng/mL in Gullele. Most of the analyzed elements, except Pb, As, Cd and Co, were found in all of the nail samples, with median (µg/g) in the range of 442‒714 Fe, 97.0‒246 Zn, 11.6‒24.1 Mn, 4.49‒5.85 Cu, 1.46‒1.66 Cr and 1.22‒1.41 Ni. The high incidence of KIM-1 indicates a potential for long term renal tubular damage among residents of the Sub-Cities. The concentrations of the elements in nails were, however, not significantly associated (p = 0.05) with the corresponding levels of KIM-1 in urine. Hence, the observed KIM-1 might be related to exposure to toxic substances or factors other than those included in this study.
Author(s): Dessie BK, Mehari B, Osman M, Gari SR, Desta AF, Melaku S, Alamirew T, Goodson ML, Walsh CL, Zeleke G, Mihret A
Publication type: Article
Publication status: Published
Journal: BioMetals
Year: 2022
Volume: 35
Pages: 1341–1358
Online publication date: 27/09/2022
Acceptance date: 17/09/2022
Date deposited: 19/12/2022
ISSN (print): 0966-0844
ISSN (electronic): 1572-8773
Publisher: Springer Nature
URL: https://doi.org/10.1007/s10534-022-00448-8
DOI: 10.1007/s10534-022-00448-8
ePrints DOI: 10.57711/4145-2p28
PubMed id: 36163536
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