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Lookup NU author(s): Dr Amardeep Khanna, Dr Manu Nayar, Dr Vinod Hegade
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© The Author(s), 2022. Background: Fully covered intraductal self-expanding metal stents (IDSEMS) have been well described in the management of post-liver transplant (LT) anastomotic strictures (ASs). Their antimigration waists and intraductal nature make them suited for deployment across the biliary anastomosis. Objectives: We conducted a multicentre study to analyse their use and efficacy in the management of AS. Design: This was a retrospective, multicentre observational study across nine tertiary centres in the United Kingdom. Methods: Consecutive patients who underwent endoscopic retrograde cholangiopancreatography with IDSEMS insertion were analysed retrospectively. Recorded variables included patient demographics, procedural characteristics, response to therapy and follow-up data. Results: In all, 162 patients (100 males, 62%) underwent 176 episodes of IDSEMS insertion for AS. Aetiology of liver disease in this cohort included hepatocellular carcinoma (n = 35, 22%), followed by alcohol-related liver disease (n = 29, 18%), non-alcoholic steatohepatitis (n = 20, 12%), primary biliary cholangitis (n = 15, 9%), acute liver failure (n = 13, 8%), viral hepatitis (n = 13, 8%) and autoimmune hepatitis (n = 12, 7%). Early AS occurred in 25 (15%) cases, delayed in 32 (20%) cases and late in 95 (59%) cases. Age at transplant was 54 years (range, 12–74), and stent duration was 15 weeks (range, 3 days–78 weeks). In total, 131 (81%) had complete resolution of stricture at endoscopic re-evaluation. Stricture recurrence was observed in 13 (10%) cases, with a median of 19 weeks (range, 4–88 weeks) after stent removal. At removal, there were 21 (12%) adverse events, 5 (3%) episodes of cholangitis and 2 (1%) of pancreatitis. In 11 (6%) cases, the removal wires unravelled, and 3 (2%) stents migrated. All were removed endoscopically. Conclusion: IDSEMS appears to be safe and highly efficacious in the management of post-LT AS, with low rates of AS recurrence.
Author(s): Ahmed W, Kyle D, Khanna A, Devlin J, Reffitt D, Zeino Z, Webster G, Phillpotts S, Gordon R, Corbett G, Gelson W, Nayar M, Khan H, Cramp M, Potts J, Fateen W, Miller H, Paranandi B, Huggett M, Everett SM, Hegade VS, O'Kane R, Scott R, McDougall N, Harrison P, Joshi D
Publication type: Article
Publication status: Published
Journal: Therapeutic Advances in Gastroenterology
Year: 2022
Volume: 15
Online publication date: 26/09/2022
Acceptance date: 24/07/2022
Date deposited: 13/10/2022
ISSN (print): 1756-283X
ISSN (electronic): 1756-2848
Publisher: SAGE Publications Ltd
URL: https://doi.org/10.1177/17562848221122473
DOI: 10.1177/17562848221122473
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