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Lookup NU author(s): Professor Andrew Trevelyan,
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2022.Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward a possible role of dendritic plateau potentials in the actual ictogenic transition, despite a substantial literature dating back 40 years regarding its importance generally in epilepsy. Here, we argue that an increase in dendritic excitability, coordinated across the population of pyramidal cells, is a key stage in ictogenesis.
Author(s): Trevelyan AJ, Graham RT, Parrish RR, Codadu NK
Publication type: Article
Publication status: Published
Journal: Epilepsy Currents
Print publication date: 01/02/2023
Online publication date: 27/09/2022
Acceptance date: 02/04/2018
Date deposited: 31/10/2022
ISSN (print): 1535-7597
ISSN (electronic): 1535-7511
Publisher: SAGE Publications Ltd
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