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Synergistic Positive Feedback Mechanisms Underlying Seizure Initiation

Lookup NU author(s): Professor Andrew Trevelyan, Ryley Parrish, Neela Codadu



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© The Author(s) 2022.Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward a possible role of dendritic plateau potentials in the actual ictogenic transition, despite a substantial literature dating back 40 years regarding its importance generally in epilepsy. Here, we argue that an increase in dendritic excitability, coordinated across the population of pyramidal cells, is a key stage in ictogenesis.

Publication metadata

Author(s): Trevelyan AJ, Graham RT, Parrish RR, Codadu NK

Publication type: Article

Publication status: Published

Journal: Epilepsy Currents

Year: 2022

Volume: 23

Issue: 1

Pages: 38-43

Print publication date: 01/02/2023

Online publication date: 27/09/2022

Acceptance date: 02/04/2018

Date deposited: 31/10/2022

ISSN (print): 1535-7597

ISSN (electronic): 1535-7511

Publisher: SAGE Publications Ltd


DOI: 10.1177/15357597221127163


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Funder referenceFunder name
BB/P019854/1Biotechnology and Biological Sciences Research Council (BBSRC)
Epilepsy Research UK
MR/R005427/1Medical Research Council (MRC)