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An electrogenetic toggle switch model

Lookup NU author(s): Dr Lewis Grozinger, Dr Elizabeth Heidrich, Dr Angel Goni-Moreno

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

© 2022 The Authors. Microbial Biotechnology published by Society for Applied Microbiology and John Wiley & Sons Ltd. Synthetic biology uses molecular biology to implement genetic circuits that perform computations. These circuits can process inputs and deliver outputs according to predefined rules that are encoded, often entirely, into genetic parts. However, the field has recently begun to focus on using mechanisms beyond the realm of genetic parts for engineering biological circuits. We analyse the use of electrogenic processes for circuit design and present a model for a merged genetic and electrogenetic toggle switch operating in a biofilm attached to an electrode. Computational simulations explore conditions under which bistability emerges in order to identify the circuit design principles for best switch performance. The results provide a basis for the rational design and implementation of hybrid devices that can be measured and controlled both genetically and electronically.

Publication metadata

Author(s): Grozinger L, Heidrich E, Goni-Moreno A

Publication type: Article

Publication status: Published

Journal: Microbial Biotechnology

Year: 2023

Volume: 16

Issue: 3

Pages: 546-559

Print publication date: 01/03/2023

Online publication date: 07/10/2022

Acceptance date: 10/09/2022

Date deposited: 26/06/2023

ISSN (electronic): 1751-7915

Publisher: John Wiley and Sons Ltd

URL: https://doi.org/10.1111/1751-7915.14153

DOI: 10.1111/1751-7915.14153

PubMed id: 36207818

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