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Lookup NU author(s): Dr Laura WrightORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Abstract Introduction: Published research reports inconsistent links between APOE-ε4 and cognition. We hypothesised that these links can be reliably captured by graph-theory analyses. Methods: Cognitive networks were calculated in 8,118 controls, 3,482 MCI patients and 4,573 Alzheimer’s dementia patients, recruited as part of the National Alzheimer’s Coordinating Center (NACC) database. Differences in nodal centrality were tested in two independent NACC sub-cohorts between ε4-carriers and non-carriers. Results: A significant APOE-dependant effect emerged from the analysis of the Logical-Memory nodes in MCI patients in both sub-cohorts. While non-carriers showed equal centrality in immediate and delayed recall, the latter was significantly less central among carriers. These findings were replicated in the sub-groups of sole amnestic-MCI patients (n = 2,971). No effects were found in the other two diagnostic groups. Discussion: APOE ε4 influences nodal properties of cognitive networks at the MCI stage. This highlights the importance of characterising the impact of risk factors on the wider cognitive network.
Author(s): De Marco M, Wright LM, Valera-Bermejo JM, Ferguson C
Publication type: Article
Publication status: Published
Journal: Neuropsychologia
Year: 2024
Volume: 192
Print publication date: 10/01/2024
Online publication date: 29/11/2023
Acceptance date: 23/11/2023
Date deposited: 19/02/2024
ISSN (print): 0028-3932
ISSN (electronic): 1873-3514
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.neuropsychologia.2023.108741
DOI: 10.1016/j.neuropsychologia.2023.108741
Data Access Statement: Data used in this study was obtained from the National Alzheimer’s Coordinating Center initiative (https://naccdata.org/).
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