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Effects of blood pressure-lowering drugs in heart failure: A systematic review andmeta-analysis of randomized controlled trials

Lookup NU author(s): Dr Dexter CanoyORCiD


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© 2019 Wolters Kluwer Health, Inc. We aimed to combine evidence from all heart failure trials that have investigated the effects of drugs with blood pressure (BP)-lowering properties to assess the extent to which such drugs reduce BP in heart failure, the association between the net change in BP between treatment arms and cause-specific outcomes and whether treatment effects (efficacy and safety) vary according to baseline BP. We conducted a systematic review and metaanalysis including randomized clinical trials of drugs with BP-lowering properties in patients with chronic heart failure with at least 300 patient-years follow-up. We included a total of 37 trials (91 950 patients) and showed that treatment with drugs with BP-lowering properties resulted in a small but significant decrease in SBP in patients with heart failure with no evidence that the efficacy and safety of those drugs varied according to baseline BP.

Publication metadata

Author(s): Pinho-Gomes A-C, Azevedo L, Bidel Z, Nazarzadeh M, Canoy D, Copland E, Salam A, Rodgers A, Kotecha D, Rahimi K

Publication type: Review

Publication status: Published

Journal: Journal of Hypertension

Year: 2019

Volume: 37

Issue: 9

Pages: 1757-1767

Print publication date: 01/09/2019

Acceptance date: 02/04/2018

ISSN (print): 0263-6352

ISSN (electronic): 1473-5598

Publisher: Lippincott Williams and Wilkins


DOI: 10.1097/HJH.0000000000002094

PubMed id: 30950980