Browse by author
Lookup NU author(s): Dr Dexter CanoyORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2019 American Medical Association. All rights reserved. Importance: Modifiable risk factors for valvular heart disease remain largely unknown, which limits prevention and treatment. Objective: To assess the association between systolic blood pressure (BP) and major valvular heart disease. Design, Setting, and Participants: A UK Biobank population-based cohort of 502602 men and women aged 40 to 96 years at baseline was evaluated through mendelian randomization using individual participant data. Inclusion criteria were valid genetic data and BP measurements. The participants were recruited between 2006 and 2010; data analysis was performed from June 2018 to January 2019. Exposures: Systolic BP was measured during clinical assessment and instruments for the genetic effect of high BP were identified from variants that were independently (linkage disequilibrium threshold of r2<0.1) associated with systolic BP with minor allele frequency greater than 0.01. A total of 130 single-nucleotide polymorphisms that have been shown to be associated with systolic BP in a genome-wide association meta-analysis involving 1 million participants of European ancestry were selected. Main Outcomes and Measures: Incident aortic stenosis, aortic regurgitation, and mitral regurgitation, individually and combined. Cases were largely based on hospital records linked to the UK Biobank with International Classification of Diseases and Health Related Problems, Tenth Revision codes. Results: Of the 502602 individuals screened, 329237 participants (177 741 [53.99%] women; mean [SD] age, 56.93 [7.99] years) had valid genetic data and BP measurements; of this cohort, 3570 individuals (1.08%) had a diagnosis of valvular heart disease (aortic stenosis, 1491 [0.45%]; aortic regurgitation, 634 [0.19%]; and mitral regurgitation, 1736 [0.53%]). Each genetically associated 20-mm Hg increment in systolic BP was associated with an increased risk of aortic stenosis (odds ratio [OR], 3.26; 95% CI, 1.50-7.10), aortic regurgitation (OR, 2.59; 95% CI, 0.75-8.92), and mitral regurgitation (OR, 2.19; 95% CI, 1.07-4.47), with no evidence for heterogeneity by type of valvular heart disease (P =.90). Sensitivity analyses confirmed the robustness of the association. Conclusions and Relevance: Lifetime exposure to elevated systolic BP appears to be associated with an increased risk of major valvular heart disease.
Author(s): Nazarzadeh M, Pinho-Gomes A-C, Smith Byrne K, Canoy D, Raimondi F, Ayala Solares JR, Otto CM, Rahimi K
Publication type: Article
Publication status: Published
Journal: JAMA Cardiology
Year: 2019
Volume: 4
Issue: 8
Pages: 788-795
Print publication date: 01/08/2019
Online publication date: 10/07/2019
Acceptance date: 08/05/2019
ISSN (print): 2380-6583
ISSN (electronic): 2380-6591
Publisher: American Medical Association
URL: https://doi.org/10.1001/jamacardio.2019.2202
DOI: 10.1001/jamacardio.2019.2202
PubMed id: 31290937
Altmetrics provided by Altmetric
