Toggle Main Menu Toggle Search

Open Access padlockePrints

Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease

Lookup NU author(s): Dr Dexter CanoyORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© European Society of Cardiology 2014.Aims Vascular disease mortality has declined rapidly in most Western countries, against a background of improved treatments and falling prevalence of smoking, but rising obesity. We examined whether this decline differed by lifestyle risk factors for vascular disease. Methods and Results During 2001-2010, there were 9241 vascular disease deaths in a prospective study of 1.3 million women in middle age, about one-quarter of all UK women in the eligible age range (50-64 years in 1996-2001). We estimated percentage declines in mortality from coronary heart disease, cerebrovascular disease and other vascular diseases, overall and by age, smoking, alcohol consumption, adiposity, physical activity, socioeconomic status and age at leaving school. Over 10 years, coronary heart disease mortality fell by half (52%), cerebrovascular disease mortality by two-fifths (42%) and other vascular disease mortality by one-fifth (22%). Lean women experienced greater declines in coronary heart disease mortality than overweight or obese women (70%, 48% and 26%, respectively; P < 0.001 for heterogeneity) and women in the highest and middle thirds of socioeconomic status experienced greater declines in other (non-coronary, non-cerebrovascular) vascular disease mortality than women in the lowest third (41% and 42% and -9%, respectively; P = 0.001). After accounting for multiple testing, there were no other significant differences in vascular mortality trends by any lifestyle risk factor, including by smoking status. Conclusion Vascular disease mortality trends varied in this cohort by adiposity and socioeconomic status, but not by smoking status or other lifestyle risk factors. Prevention and treatment of vascular disease appear not to have been equally effective in all subgroups of UK women.

Publication metadata

Author(s): Cairns BJ, Balkwill A, Canoy D, Green J, Reeves GK, Beral V

Publication type: Article

Publication status: Published

Journal: European Journal of Preventive Cardiology

Year: 2015

Volume: 22

Issue: 12

Pages: 1626-1634

Print publication date: 01/12/2015

Online publication date: 29/08/2020

Acceptance date: 20/11/2014

ISSN (print): 2047-4873

ISSN (electronic): 2047-4881

Publisher: SAGE Publications Inc.


DOI: 10.1177/2047487314563710

PubMed id: 25510657


Altmetrics provided by Altmetric