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Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Lookup NU author(s): Professor David GrahamORCiD, Dr Josh Bunce

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.


Publication metadata

Author(s): Munk P, Brinch C, Møller FD, Petersen TN, Hendriksen RS, Seyfarth AM, Kjeldgaard JS, Svendsen CA, vanBunnik B, Berglund F, Sewage Surveillance Consortium, Larsson DGJ, Koopmans M, Woolhouse M, Aarestrup M, Bunce JT

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2022

Volume: 13

Print publication date: 01/12/2022

Online publication date: 01/12/2022

Acceptance date: 20/10/2022

Date deposited: 06/12/2022

ISSN (electronic): 2041-1723

Publisher: Nature Publishing

URL: https://doi.org/10.1038/s41467-022-34312-7

DOI: 10.1038/s41467-022-34312-7


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Funding

Funder referenceFunder name
Horizon 2020

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