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Could vitamin D deficiency influence left heart ventricular geometry in youngsters with type 1 diabetes mellitus?

Lookup NU author(s): Dr Chris Kotanidis


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© 2020, Lithografia Antoniadis I - Psarras Th G.P.. All rights reserved.Background: Experimental and clinical studies have shown the cardio-protective, anti-inflammatory, and anti-athero-sclerotic actions of vitamin D. Material and Methods: We aimed to investigate a possible correlation between vitamin D status and heart geometry using echocardiographic parameters of the left ventricle in youngsters with type 1 diabetes mellitus (T1D). Seventy-eight pediatric patients (aged 13.47 ± 2.86 years) with T1D of more than two years duration and 74 healthy controls (aged 12.04 ± 2.79 years) were enrolled in this case-control study. Anthropometric parameters were recorded, vitamin D and parathormone serum levels were measured, and trans-thoracic echocardiographic study was performed. Results: Vitamin D deficiency was found in 74 % T1D patients and in 72 % of the controls, while parathormone levels were normal in both groups. T1D patients presented significantly higher values of interventricular septal thickness at diastole (IVSD) compared to controls (0.76 ± 0.16 cm vs 0.71 ± 0.14 cm, p =0.043). All other echocardiographic parameters did not exhibit significant differences between patients and controls. The diastolic function of the left ventricle (LV) was normal in both groups. After sub-grouping, the participants according to the deficiency or not of vitamin D, only patients with T1D and low vitamin D levels had increased values of IVSD compared to controls (0.78 ± 0.17 vs 0.71 ± 0.14, p =0.008). Patients with T1D and normal vitamin D levels presented similar values of IVSD compared to controls (0.71 ± 0.12 vs 0.73 ± 0.15, p =NS). Conclusions: Children and adolescents with T1D and normal vitamin D levels do not exhibit changes in LV dimensions or diastolic function, except for increased IVSD, compared to controls. Larger and longitudinal studies are required to confirm and consolidate this finding.

Publication metadata

Author(s): Kleisarchaki AN, Papadopoulou-Legbelou K, Kotanidou EP, Kotanidis CP, Eboriadou-Petikopoulou M, Galli-Tsinopoulou A

Publication type: Article

Publication status: Published

Journal: Hippokratia

Year: 2019

Volume: 23

Issue: 1

Pages: 9-14

Acceptance date: 02/04/2019

ISSN (print): 1108-4189

ISSN (electronic): 1790-8019

Publisher: Lithografia Antoniadis I - Psarras Th G.P.