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Determining the preferred liquid reward in adult C57BL/6 mice

Lookup NU author(s): Dr Amy Miller, Dr Matthew Leach

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© The Author(s) 2022. Using food rewards to motivate mice is commonplace in behavioural research. Using a reward which is highly desirable is of benefit, as it can reduce the need to food restrict animals and can encourage higher levels of consumption, allowing for changes in levels of consumption following an intervention to be easily determined. Here, we aimed to determine the preferred milk reward for adult male C57Bl/6 mice. Thirty male C57Bl/6 mice were provided with soya milk, chocolate milk, almond milk or water for a four-hour period in a cross-over design. When planning studies that involve the use of a palatable liquid reward, soya milk is the preferred option for adult male C57BL/6 mice. Providing a liquid reward of high value will give increased levels of consumption, with little or no food restriction required.

Publication metadata

Author(s): Miller AL, Leach MC

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 2023

Volume: 57

Issue: 3

Pages: 332-335

Print publication date: 01/06/2023

Online publication date: 06/12/2022

Acceptance date: 02/08/2022

Date deposited: 05/01/2023

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: SAGE Publications Ltd

URL: https://doi.org/10.1177/00236772221138628

DOI: 10.1177/00236772221138628

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