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National survey of corneal cross-linking (CXL) practice patterns in the United Kingdom during 2019

Lookup NU author(s): Professor Francisco FigueiredoORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2022, The Author(s). Objective: To provide an insight into trends in corneal cross-linking (CXL) practice in the UK, including criteria for progression of corneal ectasia, identification of patients for CXL, the CXL procedure itself and post-operative management. Methods: All ophthalmologist members of the UK Cross-linking (UK-CXL) Consortium were invited to complete an online survey about CXL practice for the year 2019. The data collected was anonymised by site and analysed with descriptive statistics. Results: Responses were received from 16 individual CXL centres (16/38; 42% response rate) and the data represented ~2,000 CXL procedures performed in the UK in 2019. The commonest indication for CXL was progressive keratoconus. Between centres, there were variations in diagnostic evaluation, patient selection for CXL, the CXL procedure and the pre- and post-operative monitoring of patients. Conclusion: Consistent with the wide number of CXL treatment techniques described in the published literature world-wide, variations in the monitoring of corneal ectasia, indications for CXL, CXL practice and post-CXL follow-up were found to exist between UK-based CXL centres.

Publication metadata

Author(s): Hayes S, Jaycock P, Rees N, Figueiredo FC, O'Brart DPS, Meek KM

Publication type: Article

Publication status: Published

Journal: Eye

Year: 2023

Volume: 37

Pages: 2511-2517

Print publication date: 01/08/2023

Online publication date: 20/12/2022

Acceptance date: 06/12/2022

Date deposited: 04/01/2023

ISSN (print): 0950-222X

ISSN (electronic): 1476-5454

Publisher: Springer Nature


DOI: 10.1038/s41433-022-02365-z


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