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Lookup NU author(s): Professor Marco Carrozzo
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Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trelat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.
Author(s): Pentenero M, Carrozzo M, Pagano M, Gandolfo S
Publication type: Article
Publication status: Published
Journal: International Journal of Dermatology
ISSN (print): 0011-9059
ISSN (electronic): 1365-4632
Publisher: Wiley-Blackwell Publishing Ltd.
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