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Oral acanthosis nigricans, tripe palms and sign of leser-trelat in a patient with gastric adenocarcinoma

Lookup NU author(s): Professor Marco Carrozzo


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Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trelat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.

Publication metadata

Author(s): Pentenero M, Carrozzo M, Pagano M, Gandolfo S

Publication type: Article

Publication status: Published

Journal: International Journal of Dermatology

Year: 2004

Volume: 43

Issue: 7

Pages: 530-532

ISSN (print): 0011-9059

ISSN (electronic): 1365-4632

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1365-4632.2004.02159.x


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