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Lookup NU author(s): Dr Monika Olahova, Professor Robert Taylor
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The AuthorsEfforts to understand how mitochondrial dysfunction contributes to neurodegeneration have primarily focussed on the role of mitochondria in neuronal energy metabolism. However, progress in understanding the etiological nature of emerging mitochondrial functions has yielded new ideas about the mitochondrial basis of neurological disease. Studies aimed at deciphering how mitochondria signal through interorganellar contacts, vesicular trafficking, and metabolic transmission have revealed that mitochondrial regulation of immunometabolism, cell death, organelle dynamics, and neuroimmune interplay are critical determinants of neural health. Moreover, the homeostatic mechanisms that exist to protect mitochondrial health through turnover via nanoscale proteostasis and lysosomal degradation have become integrated within mitochondrial signalling pathways to support metabolic plasticity and stress responses in the nervous system. This review highlights how these distinct mitochondrial pathways converge to influence neurological health and contribute to disease pathology.
Author(s): Collier JJ, Olahova M, McWilliams TG, Taylor RW
Publication type: Review
Publication status: Published
Journal: Trends in Neurosciences
Year: 2023
Volume: 46
Issue: 2
Pages: 137-152
Print publication date: 01/02/2023
Online publication date: 10/01/2023
Acceptance date: 02/04/2022
ISSN (print): 0166-2236
ISSN (electronic): 1878-108X
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.tins.2022.12.001
DOI: 10.1016/j.tins.2022.12.001
