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Mitochondrial signalling and homeostasis: from cell biology to neurological disease

Lookup NU author(s): Dr Monika Olahova, Professor Robert Taylor



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023 The AuthorsEfforts to understand how mitochondrial dysfunction contributes to neurodegeneration have primarily focussed on the role of mitochondria in neuronal energy metabolism. However, progress in understanding the etiological nature of emerging mitochondrial functions has yielded new ideas about the mitochondrial basis of neurological disease. Studies aimed at deciphering how mitochondria signal through interorganellar contacts, vesicular trafficking, and metabolic transmission have revealed that mitochondrial regulation of immunometabolism, cell death, organelle dynamics, and neuroimmune interplay are critical determinants of neural health. Moreover, the homeostatic mechanisms that exist to protect mitochondrial health through turnover via nanoscale proteostasis and lysosomal degradation have become integrated within mitochondrial signalling pathways to support metabolic plasticity and stress responses in the nervous system. This review highlights how these distinct mitochondrial pathways converge to influence neurological health and contribute to disease pathology.

Publication metadata

Author(s): Collier JJ, Olahova M, McWilliams TG, Taylor RW

Publication type: Review

Publication status: Published

Journal: Trends in Neurosciences

Year: 2023

Volume: 46

Issue: 2

Pages: 137-152

Print publication date: 01/02/2023

Online publication date: 10/01/2023

Acceptance date: 02/04/2022

ISSN (print): 0166-2236

ISSN (electronic): 1878-108X

Publisher: Elsevier Ltd


DOI: 10.1016/j.tins.2022.12.001