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Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice – A preliminary study

Lookup NU author(s): Dr Kheng-Lim GohORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023 The Authors. Mimecan, or osteoglycin, belongs to the family of small leucine-rich proteoglycans. In connective tissues mimecan is implicated in the development and maintenance of normal collagen fibrillar organization. Since collagen fibrils are responsible for tissue reinforcement, the absence of mimecan could lead to abnormal tissue mechanical properties. Here, we carried out a preliminary investigation of possible changes in the mechanical properties of tendons in mice lacking a functional mimecan gene, as a function of age. Tail tendons were dissected from mimecan gene knockout (KO) and wild type (WT) mice at ages 1, 4 and 8 months and mechanical properties evaluated using a microtensile testing equipment. Mimecan gene knockout resulted in changes in tendon elasticity- and fracture-related properties. While tendons of WT mice exhibited enhanced mechanical properties with increasing age, this trend was notably attenuated in mimecan KO tendons, with the exception of fracture strain. When genotype and age were considered as cross factors, the diminution in the mechanical properties of mimecan KO tendons was significant for yield strength, modulus and fracture strength. This effect appeared to affect the mice at 4 month old. These preliminary results suggest that mimecan may have a role in regulating age-dependent mechanical function in mouse tail tendon.

Publication metadata

Author(s): Boote C, Ma Q, Goh KL

Publication type: Article

Publication status: Published

Journal: Journal of the Mechanical Behavior of Biomedical Materials

Year: 2023

Volume: 139

Online publication date: 11/01/2023

Acceptance date: 07/01/2023

Date deposited: 30/01/2023

ISSN (print): 1751-6161

ISSN (electronic): 1878-0180

Publisher: Elsevier Ltd

DOI: 10.1016/j.jmbbm.2023.105672


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