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Lookup NU author(s): Professor David GrahamORCiD
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© 2022 SETAC. Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly understood. The abundance of ARB and ARGs is often elevated in human-impacted areas, especially in environments receiving fecal wastes, or in the presence of complex mixtures of chemical contaminants, such as pharmaceuticals and personal care products. Self-replication, mutation, horizontal gene transfer, and adaptation to different environmental conditions contribute to the persistence and proliferation of ARB in habitats under strong anthropogenic influence. Our review discusses the interplay between chemical contaminants and ARB and their respective genes, specifically in reference to co-occurrence, potential biostimulation, and selective pressure effects, and gives an overview of mitigation by existing man-made and natural barriers. Evidence and strategies to improve the assessment of human health risks due to environmental antibiotic resistance are also discussed. Environ Toxicol Chem 2023;00:1–16. © 2022 SETAC.
Author(s): Manaia CM, Aga DS, Cytryn E, Gaze WH, Graham DW, Guo J, Leonard AFC, Li L, Murray AK, Nunes OC, Rodriguez-Mozaz S, Topp E, Zhang T
Publication type: Review
Publication status: Published
Journal: Environmental Toxicology and Chemistry
Year: 2024
Volume: 43
Issue: 3
Pages: 637-652
Print publication date: 01/03/2024
Online publication date: 30/12/2022
Acceptance date: 20/12/2022
ISSN (print): 0730-7268
ISSN (electronic): 1552-8618
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/etc.5555
DOI: 10.1002/etc.5555
PubMed id: 36582150
