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Lookup NU author(s): Professor Giorgio TascaORCiD
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© 2021 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases. Mutations in myelin protein zero (MPZ) are associated with heterogeneous manifestations. In this study, we report clinical, electrophysiological, pathological, and muscle MRI findings from two relatives with MPZ Thr124Met variants, disclosing different phenotypes. The proband was a 73-year-old female with a 12-year-story of atrophy, weakness, and fasciculations in her proximal and distal lower limbs. EMG examination showed neurogenic signs with active denervation together with reduced sensory action potentials, without sensory symptoms. The initial diagnosis was of a slowly progressive lower motor neuron disease (MND) with subclinical sensory axonal neuropathy. Two years later, the observation of her 60-year-old nephew, who had a distal sensory-motor neuropathy, prompted the analysis of inherited neuropathies-related genes and revealed a MPZ Thr124Met mutation in both cases. Our findings expand the clinical spectrum of MPZ-related neuropathy and highlight that Thr124Met mutation may cause a syndrome mimicking MND. The challenging issue to detect sensory features in the diagnostic MND work up is discussed.
Author(s): Bisogni G, Romano A, Conte A, Tasca G, Bernardo D, Luigetti M, Di Paolantonio A, Fabrizi GM, Patanella AK, Meleo E, Sabatelli M
Publication type: Article
Publication status: Published
Journal: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Online publication date: 01/07/2021
Acceptance date: 14/06/2021
ISSN (print): 2167-8421
ISSN (electronic): 2167-9223
Publisher: Taylor and Francis Ltd
PubMed id: 34210210
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