Browse by author
Lookup NU author(s): Professor Giorgio TascaORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Copyright © 2019 Paoletti, Pichiecchio, Cotti Piccinelli, Tasca, Berardinelli, Padovani and Filosto.In the last years, magnetic resonance imaging (MRI) has become fundamental for the diagnosis and monitoring of myopathies given its ability to show the severity and distribution of pathology, to identify specific patterns of damage distribution and to properly interpret a number of genetic variants. The advances in MR techniques and postprocessing software solutions have greatly expanded the potential to assess pathological changes in muscle diseases, and more specifically of myopathies; a number of features can be studied and quantified, ranging from composition, architecture, mechanical properties, perfusion, and function, leading to what is known as quantitative MRI (qMRI). Such techniques can effectively provide a variety of information beyond what can be seen and assessed by conventional MR imaging; their development and application in clinical practice can play an important role in the diagnostic process and in assessing disease course and treatment response. In this review, we briefly discuss the current role of muscle MRI in diagnosing muscle diseases and describe in detail the potential and perspectives of the application of advanced qMRI techniques in this field.
Author(s): Paoletti M, Pichiecchio A, Piccinelli SC, Tasca G, Berardinelli AL, Padovani A, Filosto M
Publication type: Review
Publication status: Published
Journal: Frontiers in Neurology
Year: 2019
Volume: 10
Print publication date: 01/02/2019
Online publication date: 11/02/2019
Acceptance date: 21/01/2019
ISSN (electronic): 1664-2295
Publisher: Frontiers Media S.A.
URL: https://doi.org/10.3389/fneur.2019.00078
DOI: 10.3389/fneur.2019.00078
