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Expert Panel Consensus on Clinical Assertion Statements Describing Noninvasive Tools for Diagnosing Nonalcoholic Steatohepatitis

Lookup NU author(s): Professor Quentin AnsteeORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.GOALS AND BACKGROUND: A panel of 9 experts in nonalcoholic steatohepatitis gathered to assess multiple components of the diagnostic process. MATERIALS AND METHODS: The Clinical Assertion Statements covered screening of patients with type 2 diabetes for high-risk nonalcoholic fatty liver disease, which-if any-noninvasive tests could determine whether to delay or defer biopsy, whether primary care providers and endocrinologists should routinely calculate Fibrosis-4 (FIB-4) scores in patients with nonalcoholic fatty liver disease or those at risk for it, optimal noninvasive tests to stage fibrosis, the need to consider fibrosis in patients with normal transaminase levels, periodic monitoring for progressive fibrosis, whether patients should undergo biopsy before pharmacotherapy, and the clinical utility of genetic testing. RESULTS AND CONCLUSIONS: Evidence was presented to support or refute each Clinical Assertion Statement; the panel voted on the nature of the evidence, level of support, and level of agreement with each Statement. Panel level of agreement and rationale of each Clinical Assertion Statement are reported here.


Publication metadata

Author(s): Jacobson IM, Wong VW-S, Castera L, Anstee QM, Noureddin M, Cusi K, Harrison SA, Bugianesi E, Younossi ZM

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Gastroenterology

Year: 2023

Volume: 57

Issue: 3

Pages: 253-264

Print publication date: 01/03/2023

Acceptance date: 02/04/2022

Date deposited: 28/02/2023

ISSN (print): 0192-0790

ISSN (electronic): 1539-2031

Publisher: Lippincott Williams & Wilkins

URL: https://doi.org/10.1097/MCG.0000000000001780

DOI: 10.1097/MCG.0000000000001780

PubMed id: 36251413


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