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Factors related with sarcopenia and sarcopenic obesity among low- and middle-income settings: the 10/66 DRG study

Lookup NU author(s): Professor Matthew Prina

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2020, The Author(s). Sarcopenia and sarcopenic obesity research in low- and middle- income countries (LMICs) is limited. We investigated sarcopenia and sarcopenic obesity prevalence and sociodemographic, bio-clinical and lifestyle factors in LMICs settings. For the purposes of this study, the 10/66 Dementia Research Group follow-up wave information from individuals aged 65 and over in Cuba, Dominican Republic, Peru, Mexico, Puerto Rico, China, was employed and analysed (n = 8.694). Based on indirect population formulas, we calculated body fat percentage (%BF) and skeletal muscle mass index (SMI). Sarcopenia prevalence ranged from 12.4% (Dominican Republic) to 24.6% (rural Peru); sarcopenic obesity prevalence ranged from 3.0% (rural China) to 10.2% (rural Peru). Odds ratios (OR) with 95% confidence intervals (CI) for sarcopenia were higher for men 2.82 (2.22–3.57) and those with higher %BF 1.08 (1.07–1.09), whereas higher number of assets was associated with a decreased likelihood 0.93 (0.87–1.00). OR of sarcopenic obesity were higher for men 2.17 (1.70–2.76), those reporting moderate alcohol drinking 1.76 (1.21–2.57), and those with increased number of limiting impairments 1.54 (1.11–2.14). We observed heterogeneity in the prevalence of sarcopenia and sarcopenic obesity in the 10/66 settings. We also found a variety of factors to be associated with those. Our results reveal the need for more research among the older population of LMICs.


Publication metadata

Author(s): Daskalopoulou C, Wu Y-T, Pan W, Gine Vazquez I, Prince M, Prina M, Tyrovolas S

Publication type: Article

Publication status: Published

Journal: Scientific Reports

Year: 2020

Volume: 10

Issue: 1

Online publication date: 24/11/2020

Acceptance date: 07/09/2020

Date deposited: 14/08/2023

ISSN (electronic): 2045-2322

Publisher: Nature Research

URL: https://doi.org/10.1038/s41598-020-76575-4

DOI: 10.1038/s41598-020-76575-4

PubMed id: 33235211


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Funding

Funder referenceFunder name
European Research Council
ERC-2013-ADG 340755 LIFE2YEARS1066
Fondos Europeos de Desarrollo Regional
Foundation for Education and European Culture
MRC
Miguel Servet programme
MR/K021907/1
US Alzheimer’s Association
World Health Organization
Wellcome Trust Health Consequences of Population Change Programme

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