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Lookup NU author(s): Dr Mark Pennington, Professor Matthew Prina
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© 2019 Author(s). Introduction Cost-effectiveness analyses that use quality-adjusted life-years (QALYs) allow comparing the value for money of interventions across different health problems. Health state utility values (HSUVs) are crucial to calculate QALYs. These are weights attached to a given health state reflecting preferences in health-related quality of life (HRQoL). In schizophrenia, there is extensive evidence about the consequences of this condition on HRQoL. Besides, several interventions have claimed to be cost-effective in terms of QALYs gained. Despite this evidence, a systematic review of HSUVs has not been conducted. Therefore, we aim to synthesise the evidence about HSUVs in schizophrenia. Methods and analysis We will conduct a systematic review of the literature about HSUVs in people with schizophrenia following the Preferred Reporting Items for Systematic review and Meta-Analysis and the International Society for Pharmacoeconomics and Outcomes Research task force recommendations. The submissions records of eight electronic peer-reviewed databases and three health technology assessment (HTA) agencies will be searched. Quantitative synthesis will be carried out in comparable studies, using random-effects meta-analysis. Heterogeneity will be explored using meta-regression if more than 10 studies per covariate are found. A narrative synthesis and methodological quality of included studies will be also reported. Discussion This review will provide a synthesis of the HSUVs estimated for different states experienced by people with schizophrenia. This will inform analysts when calculating QALYs, using values in a more transparent and accountable manner. Finally, it will shed light on evidence gaps and limitations about this measure in mental health. PROSPERO registration number CRD42019123582.
Author(s): Aceituno D, Pennington M, Iruretagoyena B, Prina MA, McCrone P
Publication type: Article
Publication status: Published
Journal: Evidence-Based Mental Health
Year: 2019
Volume: 22
Issue: 4
Pages: 142-144
Print publication date: 01/11/2019
Online publication date: 24/05/2019
Acceptance date: 29/04/2019
ISSN (electronic): 2755-9734
Publisher: BMJ Publishing Group
URL: https://doi.org/10.1136/ebmental-2019-300089
DOI: 10.1136/ebmental-2019-300089
PubMed id: 31126911
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