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Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions

Lookup NU author(s): Professor Moein MoghimiORCiD, Hajira -

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2023 The AuthorsThe complement system, professional phagocytes and other cells such as Natural killer cells and mast cells are among the important components of the innate arm of the immune system. These constituents provide an orchestrated array of defences and responses against tissue injury and foreign particles, including nanopharmaceuticals. While interception of nanopharmaceuticals by the immune system is beneficial for immunomodulation and treatment of phagocytic cell disorders, it is imperative to understand the multifaceted mechanisms by which nanopharmaceuticals interacts with the immune system and evaluate the subsequent balance of beneficial versus adverse reactions. An example of the latter is adverse infusion reactions to regulatory-approved nanopharmaceuticals seen in human subjects. Here, we discuss collective opinions and findings from our laboratories in mapping nanoparticle-mediated complement and leucocyte/macrophage responses.

Publication metadata

Author(s): Moghimi SM, Haroon HB, Yaghmur A, Hunter AC, Papini E, Farhangrazi ZS, Simberg D, Trohopoulos PN

Publication type: Article

Publication status: Published

Journal: Journal of Controlled Release

Year: 2023

Volume: 356

Pages: 115-129

Print publication date: 01/04/2023

Online publication date: 02/03/2023

Acceptance date: 15/02/2023

Date deposited: 21/03/2023

ISSN (print): 0168-3659

ISSN (electronic): 1873-4995

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.jconrel.2023.02.022

DOI: 10.1016/j.jconrel.2023.02.022

PubMed id: 36841287

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