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Lookup NU author(s): Professor Madeleine Murtagh, Emeritus Professor Paul BurtonORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
© The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease.Optimizing research on the developmental origins of health and disease (DOHaD) involves implementing initiatives maximizing the use of the available cohort study data; achieving sufficient statistical power to support subgroup analysis; and using participant data presenting adequate follow-up and exposure heterogeneity. It also involves being able to undertake comparison, cross-validation, or replication across data sets. To answer these requirements, cohort study data need to be findable, accessible, interoperable, and reusable (FAIR), and more particularly, it often needs to be harmonized. Harmonization is required to achieve or improve comparability of the putatively equivalent measures collected by different studies on different individuals. Although the characteristics of the research initiatives generating and using harmonized data vary extensively, all are confronted by similar issues. Having to collate, understand, process, host, and co-analyze data from individual cohort studies is particularly challenging. The scientific success and timely management of projects can be facilitated by an ensemble of factors. The current document provides an overview of the 'life course' of research projects requiring harmonization of existing data and highlights key elements to be considered from the inception to the end of the project.
Author(s): Fortier I, Wey TW, Bergeron J, Pinot De Moira A, Nybo-Andersen A-M, Bishop T, Murtagh MJ, Miocevic M, Swertz MA, Van Enckevort E, Marcon Y, Mayrhofer MT, Ornelas JP, Sebert S, Santos AC, Rocha A, Wilson RC, Griffith LE, Burton P
Publication type: Article
Publication status: Published
Journal: Journal of Developmental Origins of Health and Disease
Year: 2023
Volume: 14
Issue: 2
Pages: 190-198
Print publication date: 01/04/2023
Online publication date: 12/08/2022
Acceptance date: 06/07/2022
Date deposited: 29/03/2023
ISSN (print): 2040-1744
ISSN (electronic): 2040-1752
Publisher: Cambridge University Press
URL: https://doi.org/10.1017/S2040174422000460
DOI: 10.1017/S2040174422000460
PubMed id: 35957574
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