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Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis

Lookup NU author(s): Dr Paul Donaghy, Dr Dag Aarsland, Dr Joseph Kane, Professor Alan ThomasORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


INTRODUCTION: Operationalised research criteria for mild cognitive impairment with Lewy bodies(MCI-LB) were published in 2020. The aim of this systematic review and meta-analysis was to reviewthe evidence for the diagnostic clinical features and biomarkers in MCI-LB set out in the criteria. METHODS: MEDLINE, PubMed and Embase were searched on 9/28/22 for relevant articles. Articleswere included if they presented original data reporting the rates of diagnostic features in MCI-LB. RESULTS: 57 articles were included. The meta-analysis supported the inclusion of the current clinical features in the diagnostic criteria. Evidence for striatal dopaminergic imaging and metaiodobenzylguanidinecardiac scintigraphy, though limited, supports their inclusion. Quantitative EEGand fluorodeoxyglucose PET show promise as diagnostic biomarkers. DISCUSSION: The available evidence largely supports the current diagnostic criteria for MCI-LB. Further evidence will help refine the diagnostic criteria and understand how best to apply them in clinical practice and research.

Publication metadata

Author(s): Donaghy PC, Carrarini C, Ferreira D, Habich A, Aarsland D, Babiloni C, Bayram E, Kane JPM, Lewis SJG, Pilotto A, Thomas AJ, Bonanni L

Publication type: Article

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2023

Volume: 19

Issue: 7

Pages: 3186-3202

Print publication date: 01/07/2023

Online publication date: 24/04/2023

Acceptance date: 23/03/2023

Date deposited: 26/04/2023

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/alz.13105


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Swedish Research Council