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Passive and active markers of cortical excitability in epilepsy

Lookup NU author(s): Professor Yujiang WangORCiD

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Abstract

© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.Electroencephalography (EEG) has been the primary diagnostic tool in clinical epilepsy for nearly a century. Its review is performed using qualitative clinical methods that have changed little over time. However, the intersection of higher resolution digital EEG and analytical tools developed in the past decade invites a re-exploration of relevant methodology. In addition to the established spatial and temporal markers of spikes and high-frequency oscillations, novel markers involving advanced postprocessing and active probing of the interictal EEG are gaining ground. This review provides an overview of the EEG-based passive and active markers of cortical excitability in epilepsy and of the techniques developed to facilitate their identification. Several different emerging tools are discussed in the context of specific EEG applications and the barriers we must overcome to translate these tools into clinical practice.

Publication metadata

Author(s): Ramantani G, Westover MB, Gliske S, Sarnthein J, Sarma S, Wang Y, Baud MO, Stacey WC, Conrad EC

Publication type: Article

Publication status: Published

Journal: Epilepsia

Year: 2023

Volume: 64

Issue: S3

Pages: S25-S36

Print publication date: 01/12/2023

Online publication date: 10/03/2023

Acceptance date: 07/03/2023

Date deposited: 11/04/2023

ISSN (print): 0013-9580

ISSN (electronic): 1528-1167

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1111/epi.17578

DOI: 10.1111/epi.17578

PubMed id: 36897228

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