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Lookup NU author(s): Dr Urs Mosimann
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Eye movement behaviour during visual exploration of 24 patients with probable Alzheimer's disease and 24 age-matched controls was compared in a clock reading task. Controls were found to focus exploration on distinct areas at the end of each clock hand. The sum of these two areas of highest fixation density was defined as the informative region of interest (ROI). In Alzheimer's disease patients, visual exploration was less focused, with fewer fixations inside the ROI, and the time until the first fixation was inside the ROI was significantly delayed. Changes of fixation distribution correlated significantly with the ability to read the clock correctly, but did not correlate with dementia severity. In Alzheimer's disease patients, fixations were longer and saccade amplitudes were smaller. The altered visual exploration in Alzheimer's disease might be related to parietal dysfunction or to an imbalance between a degraded occipito-parietal and relatively preserved occipito-temporal visual network.
Author(s): Mosimann UP, Felblinger J, Ballinari P, Hess CW, Muri RM
Publication type: Article
Publication status: Published
Journal: Brain
Year: 2004
Volume: 127
Issue: 2
Pages: 431-438
Print publication date: 22/12/2003
ISSN (print): 0006-8950
ISSN (electronic): 1460-2156
Publisher: Oxford University Press
URL: http://dx.doi.org/10.1093/brain/awh051
DOI: 10.1093/brain/awh051
PubMed id: 14691059
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