Browse by author
Lookup NU author(s): Professor Colin Harwood
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The vast majority of genomic sequences are automatically annotated using various software programs. The accuracy of these annotations depends heavily on the very few manual annotation efforts that combine verified ex- perimental data with genomic sequences from model organisms. Here, we summarize the updated functional annotation of Bacillus subtilis strain 168, a quarter century after its genome sequence was first made public. Since the last such effort 5 years ago, 1168 genetic functions have been updated, allow- ing the construction of a new metabolic model of this organism of environmen- tal and industrial interest. The emphasis in this review is on new metabolic insights, the role of metals in metabolism and macromolecule biosynthesis, functions involved in biofilm formation, features controlling cell growth, and finally, protein agents that allow class discrimination, thus allowing mainte- nance management, and accuracy of all cell processes. New ‘genomic ob- jects’ and an extensive updated literature review have been included for the sequence, now available at the International Nucleotide Sequence Database Collaboration (INSDC: AccNum AL009126.4).
Author(s): Bremer E, Calteau A, Danchin A, Harwood C, Helmann JD, Médigue C, Palsson BO, Sekowska A, Vallenet D, Zuniga A, Zuniga C
Publication type: Article
Publication status: Published
Journal: Microbial Biotechnology
Year: 2023
Volume: 16
Issue: 6
Pages: 1203-1231
Print publication date: 01/06/2023
Online publication date: 01/04/2023
Acceptance date: 20/03/2023
Date deposited: 12/04/2023
ISSN (electronic): 1751-7915
Publisher: Wiley-Blackwell Publishing Ltd.
URL: https://doi.org/10.1111/1751-7915.14257
DOI: 10.1111/1751-7915.14257
ePrints DOI: 10.57711/n4xe-1130
PubMed id: 37002859
Altmetrics provided by Altmetric
