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Outcome of SARS-CoV2 infection in hematopoietic stem cell transplant recipients for autoimmune diseases

Lookup NU author(s): Professor Matthew CollinORCiD

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Abstract

© 2023 The AuthorsHematopoietic stem cell transplant (HSCT) recipients may be at high risk of mortality from coronavirus disease 2019 (COVID-19). However, specific data on COVID-19 after treatment with HSCT in patients affected by autoimmune diseases (ADs) are still lacking. In this multicenter observational study of the European Society for Blood and Marrow Transplantation (EBMT), clinical data on COVID-19 in 11 patients affected by severe ADs treated with HSCT (n = 3 allogeneic transplant; n = 8 autologous transplant) are reported. All patients were symptomatic during the initial phase of the SARS-CoV-2 infection. At screening, 5 patients reported upper respiratory symptoms, 3 patients had cough without oxygen requirement, and 6 patients exhibited extra-pulmonary symptoms. Four cases developed a lower respiratory tract disease (LRTD). Hospitalization was required in 6 cases, without necessity of intensive care unit (ICU) admission and/or ventilation/supplemental oxygen. Different interventions were adopted: remdesivir (n = 1), nirmatrelvir/ritonavir (n = 1), sotrovimab (n = 1), immunoglobulins (n = 1). At last follow-up, all patients are alive and had resolution of the infection. The current analysis describing the mild-moderate course of COVID-19 in transplant recipients affected by ADs, similar to the course observed in ADs under standard treatments, provides useful information to support the delivery of HSCT programs in this field. Vaccination and new treatments available for SARS-CoV-2 may be useful to further minimize the risk of infection.

Publication metadata

Author(s): Greco R, Snowden JA, Knelange NS, Tridello G, Cacciatore C, Xhaard A, Ciceri F, Collin M, Ferra C, De Becker A, Badoglio M, Averbuch D, Alexander T, Ljungman P, De la Camara R

Publication type: Article

Publication status: Published

Journal: Journal of Autoimmunity

Year: 2023

Volume: 136

Print publication date: 01/04/2023

Online publication date: 02/03/2023

Acceptance date: 28/02/2023

Date deposited: 17/04/2023

ISSN (print): 0896-8411

ISSN (electronic): 1095-9157

Publisher: Academic Press

URL: https://doi.org/10.1016/j.jaut.2023.103024

DOI: 10.1016/j.jaut.2023.103024

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