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Lookup NU author(s): Professor Neil RajanORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023. Background: Visceral malignancies in patients with Lynch syndrome behave less aggressively than in those without Lynch syndrome. The behavior of sebaceous carcinoma (SC) in Muir-Torre syndrome (MTS), a variant of Lynch syndrome, is incompletely investigated. Objective: To investigate features and survival of SC patients with and without MTS. Methods: Retrospective cohort study in the Surveillance, Epidemiology, and End Results 17 database from 2000 to 2019 of patients with SC. Patients were classified as MTS or non-MTS cases based on a threshold score of 2 on the Mayo MTS risk score. Results: We identified 105 (2.8%) MTS cases and 3677 (97.2%) non-MTS cases. On univariate analysis, MTS patients were younger, had a higher proportion of tumors outside the head/neck, and had fewer high-grade tumors. On Kaplan-Meier analysis, MTS patients trended toward having better SC-specific survival. On multivariate Cox proportional hazards analysis adjusting for other covariates, MTS status was an independent predictor of worse overall survival. However, there was no association between MTS status and SC-specific survival. Limitations: Given relatively high disease-specific survival in SC, our study may have been underpowered to detect a difference on Kaplan-Meier analysis. Conclusions: Our study suggests SC does not behave more aggressively in patients with MTS.
Author(s): Maloney NJ, Zacher NC, Hirotsu KE, Rajan N, Aasi SZ, Kibbi N
Publication type: Article
Publication status: Published
Journal: Journal of the American Academy of Dermatology
Year: 2023
Volume: 89
Issue: 2
Pages: 269-273
Print publication date: 01/08/2023
Online publication date: 31/03/2023
Acceptance date: 24/03/2023
Date deposited: 22/11/2023
ISSN (print): 0190-9622
ISSN (electronic): 1097-6787
Publisher: Elsevier Inc.
URL: https://doi.org/10.1016/j.jaad.2023.03.032
DOI: 10.1016/j.jaad.2023.03.032
ePrints DOI: 10.57711/h7c1-tb68
PubMed id: 37003478
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