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Comparison of clinicopathologic features, survival, and demographics in sebaceous carcinoma patients with and without Muir-Torre syndrome

Lookup NU author(s): Professor Neil RajanORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023. Background: Visceral malignancies in patients with Lynch syndrome behave less aggressively than in those without Lynch syndrome. The behavior of sebaceous carcinoma (SC) in Muir-Torre syndrome (MTS), a variant of Lynch syndrome, is incompletely investigated. Objective: To investigate features and survival of SC patients with and without MTS. Methods: Retrospective cohort study in the Surveillance, Epidemiology, and End Results 17 database from 2000 to 2019 of patients with SC. Patients were classified as MTS or non-MTS cases based on a threshold score of 2 on the Mayo MTS risk score. Results: We identified 105 (2.8%) MTS cases and 3677 (97.2%) non-MTS cases. On univariate analysis, MTS patients were younger, had a higher proportion of tumors outside the head/neck, and had fewer high-grade tumors. On Kaplan-Meier analysis, MTS patients trended toward having better SC-specific survival. On multivariate Cox proportional hazards analysis adjusting for other covariates, MTS status was an independent predictor of worse overall survival. However, there was no association between MTS status and SC-specific survival. Limitations: Given relatively high disease-specific survival in SC, our study may have been underpowered to detect a difference on Kaplan-Meier analysis. Conclusions: Our study suggests SC does not behave more aggressively in patients with MTS.

Publication metadata

Author(s): Maloney NJ, Zacher NC, Hirotsu KE, Rajan N, Aasi SZ, Kibbi N

Publication type: Article

Publication status: Published

Journal: Journal of the American Academy of Dermatology

Year: 2023

Volume: 89

Issue: 2

Pages: 269-273

Print publication date: 01/08/2023

Online publication date: 31/03/2023

Acceptance date: 24/03/2023

Date deposited: 22/11/2023

ISSN (print): 0190-9622

ISSN (electronic): 1097-6787

Publisher: Elsevier Inc.


DOI: 10.1016/j.jaad.2023.03.032

ePrints DOI: 10.57711/h7c1-tb68

PubMed id: 37003478


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