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Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

Lookup NU author(s): Dr Rachael LawsonORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023 International Parkinson and Movement Disorder Society.Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

Publication metadata

Author(s): Gonzalez MC, Tovar-Rios DA, Alves G, Dalen I, Williams-Gray CH, Camacho M, Forsgren L, Backstrom D, Lawson RA, Macleod AD, Counsell CE, Paquet C, DeLena C, D'Antonio F, Pilotto A, Padovani A, Blanc F, Falup-Pecurariu C, Lewis SJG, Rejdak K, Papuc E, Hort J, Nedelska Z, O'Brien J, Bonanni L, Marquie M, Boada M, Pytel V, Abdelnour C, Alcolea D, Beyer K, Tysnes O-B, Aarsland D, Maple-Grodem J

Publication type: Article

Publication status: Published

Journal: Movement Disorders Clinical Practice

Year: 2023

Volume: 10

Issue: 6

Pages: 980-986

Print publication date: 01/06/2023

Online publication date: 18/04/2023

Acceptance date: 29/03/2023

Date deposited: 10/07/2023

ISSN (electronic): 2330-1619

Publisher: John Wiley and Sons Inc


DOI: 10.1002/mdc3.13752

ePrints DOI: 10.57711/k2k9-z260


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Funder referenceFunder name
Academy of Medical Sciences
Cure Parkinson's Trust
Familjen Erling-Perssons Stiftelse
Instituto de Salud Carlos III
Generalitat de Catalunya
Helse Vest
Knut och Alice Wallenbergs Stiftelse
Medicinska Forskningsrådet
Parkinson's UK
Umeå Universitet
Universitetet i Stavanger
Wellcome Trust