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An Update on Anti-thrombotic Therapy following Transcatheter Aortic Valve Implantation: Expert Cardiologist Opinion from a UK and Ireland Delphi Group

Lookup NU author(s): Professor Azfar ZamanORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

© The Author(s) 2023.Transcatheter aortic valve implantation (TAVI) is an effective and established treatment for symptomatic aortic stenosis. However, there is a lack of consensus concerning the need for peri- and post-procedural anti-thrombotic medication. Contemporary guidelines recommend that anti-thrombotic therapy is balanced against a patient’s bleeding risk following TAVI, but do not fully consider the evolving evidence base. The purpose of the Delphi panel recommendations presented here is to provide a consensus elicited from a panel of experts who regularly prescribe anti-thrombotic therapy post-TAVI. The goal was to address evidence gaps across four key topics: anti-thrombotic therapy (anti-platelet and/or anti-coagulant) in TAVI patients in sinus rhythm; anti-thrombotic therapy in TAVI patients with AF; direct oral anti-coagulants versus vitamin K antagonists; and the need for UK/Ireland specific guidance. This consensus statement aims to inform clinical decision-making by providing a concise, evidence-based summary of best practice for prescribing anti-thrombotic therapies following TAVI and highlights areas where further research is needed.


Publication metadata

Author(s): Zaman A, Prendergast B, Hildick-Smith D, Blackman D, Anderson R, Spence MS, Mylotte D, Smith D, Wilding B, Chapman C, Atkins K, Pollock KG, Qureshi AC, Banning A

Publication type: Article

Publication status: Published

Journal: Interventional Cardiology: Reviews, Research, Resources

Year: 2023

Volume: 18

Online publication date: 10/04/2023

Acceptance date: 11/10/2022

Date deposited: 07/06/2023

ISSN (print): 1756-1477

ISSN (electronic): 1756-1485

Publisher: Radcliffe Medical Media

URL: https://doi.org/10.15420/ICR.2022.11

DOI: 10.15420/ICR.2022.11


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Funding

Funder referenceFunder name
BMS
Pfizer

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