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Reliability of patient-reported comorbidities: a systematic review and meta-analysis

Lookup NU author(s): Alice Lin, Professor David Deehan


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© The Author(s) 2021. Published by Oxford University Press on behalf of Postgraduate Medical Journal. All rights reserved. For permissions, please e-mail: Self-reported questionnaires have become a widely adopted method of reviewing patients in clinical practice. This systematic review aimed to determine the reliability of patient-reported comorbidities and to identify which patient factors influence the reliability. Included studies assessed the reliability of at least one patient-reported comorbidity against their medical record or clinical assessment as gold standard. Twenty-four eligible studies were included in the meta-analysis. Only endocrine diseases (Cohen's Kappa Coefficient (CKC) 0.81 (95% CI 0.76 to 0.85)), consisting of diabetes mellitus (CKC 0.83 (95% CI 0.80 to 0.86)) and thyroid disease (CKC 0.68 (95% CI 0.50 to 0.86)), showed good-to-excellent reliability. Factors most frequently reported to influence concordance included age, sex and educational level. This systematic review demonstrated poor-to-moderate reliability for most systems, except for endocrine which showed good-to-excellent reliability. Although patient self-reporting can be a useful guide to clinical management, several patient factors were demonstrated to affect reliability therefore it should be avoided as a standalone measure.

Publication metadata

Author(s): Lin CMA, Ng N, Orman A, Clement ND, Deehan DJ

Publication type: Article

Publication status: Published

Journal: Postgraduate Medical Journal

Year: 2023

Volume: 99

Issue: 1169

Pages: 127-138

Print publication date: 01/03/2023

Online publication date: 13/10/2021

Acceptance date: 18/09/2021

ISSN (print): 0032-5473

ISSN (electronic): 1469-0756

Publisher: Oxford University Press


DOI: 10.1136/postgradmedj-2021-140857

PubMed id: 37222068


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