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Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska, Dr Keith Gray, Thomas Lewis, Professor Richard Walker, Dr Catherine DotchinORCiD, Dr Stella Paddick
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023, The Author(s). Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa. This study aims to investigate the prevalence of psychiatric disorders in PLWH aged ≥ 50 years in Tanzania focussing on prevalence and 2-year outcomes of depression. PLWH aged ≥ 50 were systematically recruited from an outpatient clinic and assessed using the Mini-International Neuropsychiatric Interview (MINI). Neurological and functional impairment was assessed at year 2 follow-up. At baseline, 253 PLWH were recruited (72.3% female, median age 57, 95.5% on cART). DSM-IV depression was highly prevalent (20.9%), whereas other DSM-IV psychiatric disorders were uncommon. At follow-up (n = 162), incident cases of DSM-IV depression decreased from14.2 to 11.1% (χ2: 2.48, p = 0.29); this decline was not significant. Baseline depression was associated with increased functional and neurological impairment. At follow-up, depression was associated with negative life events (p = 0.001), neurological impairment (p < 0.001), and increased functional impairment (p = 0.018), but not with HIV and sociodemographic factors. In this setting, depression appears highly prevalent and associated with poorer neurological and functional outcomes and negative life events. Depression may be a future intervention target.
Author(s): Dua D, Stubbs O, Urasa S, Rogathe J, Duijinmaijer A, Howlett W, Dekker M, Kisoli A, MukaetovaLadinska EB, Gray WK, Lewis T, Walker RW, Dotchin CL, Lwezuala B, Makupa PC, Paddick SM
Publication type: Article
Publication status: Published
Journal: Journal of NeuroVirology
Year: 2023
Volume: 29
Pages: 425–439
Online publication date: 25/05/2023
Acceptance date: 19/04/2023
Date deposited: 07/06/2023
ISSN (print): 1355-0284
ISSN (electronic): 1538-2443
Publisher: Springer Nature
URL: https://doi.org/10.1007/s13365-023-01140-4
DOI: 10.1007/s13365-023-01140-4
PubMed id: 37227670
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