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Time-dependent hierarchical organization of spatial working memory: a transcranial magnetic stimulation study

Lookup NU author(s): Dr Urs Mosimann

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Abstract

The performance of memory-guided saccades with two different delays (3 and 30 s of memorization) was studied in seven healthy subjects. Double-pulse transcranial magnetic stimulation (dTMS) with an interstimulus interval of 100 ms was applied over the right dorsolateral prefrontal cortex (DLPFC) early (1 s after target presentation) and late (28 s after target presentation). Early stimulation significantly increased in both delays the percentage of error in amplitude (PEA) of contralateral memory-guided saccades compared to the control experiment without stimulation. dTMS applied late in the delay had no significant effect on PEA. Furthermore, we found a significantly smaller effect of early stimulation in the long-delay paradigm. These results suggest a time-dependent hierarchical organization of the spatial working memory with a functional dominance of DLPFC during the early memorization, independent from the memorization delay. For a long memorization delay, however, working memory seems to have an additional, DLPFC-independent component.

Publication metadata

Author(s): Mosimann UP; Nyffeler T; Pierrot-Deseilligny C; Felblinger J; Hess CW; Muri RM

Publication type: Article

Publication status: Published

Journal: European Journal of Neuroscience

Year: 2002

Volume: 16

Issue: 9

Pages: 1823-1827

ISSN (print): 0953-816X

ISSN (electronic): 1460-9568

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.1460-9568.2002.02252.x

DOI: 10.1046/j.1460-9568.2002.02252.x

PubMed id: 12431236

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